* The Sheltering Sky (1949)
* Edderkoppens hus (1955)
* The Recognities (1955)
* Augustin (1956)
* Terningmannen (1971)
* Gravity's Rainbow (1973)
* Time's Arrow (1990)
* Mason &Dixon (1997)
* Mot dagen (2006)
* The System of the World (2006)
* Underverden (1997)
Noveller:
* "The Rocket Man" (1946)
* "Sone" (1947)
* "Sjømannen som falt fra nåde med havet" (1956)
* "Driblet" (1957)
* "The Real Thing" (1983)
* "Beyond the Zero" (1985)
* "Scurrying Fuzzy" (1986)
* "Entropy" (1990)
* "Vineland" (1994)
Faglitteratur:
* The Crying of Lot 49 (1966)
* White Noise (1985)
* Underverden (1997)
* Don DeLillo om Amerika (2003)
* The Body Artist (2001)
* Falling Man (2007)
* Point Omega (2010)
* Engelen Esmeralda (2011)
* Zero K (2016)