* Daniel Hillard / Mrs. Doubtfire - Robin Williams
* Miranda Hillard - Sally Field
* Stuart Dunmeyer - Pierce Brosnan
* Lydia Hillard - Lisa Jakub
* Chris Hillard - Matthew Lawrence
* Natalie Hillard - Mara Wilson
* Frank Hillard - Harvey Fierstein
* Gloria Chaney - Polly Holliday
* Andre - Anne Haney
Støttekarakterer
* Jack McAllister - Kevin Dunn
* Jonathan Lundy - Scott Capurro
* Dommer Ira Knott - Robert Prosky
* Mr. Sprinkles - Bobcat Goldthwait
* Celeste - Lisa Jakub (ukreditert)
* Jason Hillard - Matthew Lawrence (ukreditert)
* Nicole Hillard - Mara Wilson (ukreditert)